The replication of influenza A viruses in organ cultures of human nasal polyps
Identifieur interne : 002683 ( Main/Exploration ); précédent : 002682; suivant : 002684The replication of influenza A viruses in organ cultures of human nasal polyps
Auteurs : V. P. Ginzburg [Russie] ; E. E. Rosina [Russie] ; O. K. Sharova [Russie] ; Y. Z. Ghendon [Russie]Source :
- Archives of Virology [ 0304-8608 ] ; 1982-12-01.
English descriptors
- Teeft :
- Antigenic formula, Avian, Avian influenza, Avian strains, Different strains, Histological changes, Influenza, Influenza virus, Influenza viruses, Nasal polyps, Natural infections, Organ, Organ culture, Organ cultures, Polyp, Replication, Respiratory tract, Viral preparations, Virus, Virus replication.
Abstract
Summary: Organ cultures of human nasal polyps were shown to support the replication of five out of seven human influenza A viruses and three out of six avian strains with varying degrees of efficiency. The ability to replicate was independent of the antigenic formula of the virus. The structure of nasal polyps closely resembled that of normal nasal mucosa and infection with influenza A virus resulted in histological changes analogous to those seen in natural infections. This system provides anin vitro method for more detailed studies of influenza A virus and possibly other respiratory virus infections of man.
Url:
DOI: 10.1007/BF01314162
Affiliations:
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The ability to replicate was independent of the antigenic formula of the virus. The structure of nasal polyps closely resembled that of normal nasal mucosa and infection with influenza A virus resulted in histological changes analogous to those seen in natural infections. This system provides anin vitro method for more detailed studies of influenza A virus and possibly other respiratory virus infections of man.</div></front></TEI><affiliations><list><country><li>Russie</li></country><region><li>District fédéral central</li></region><settlement><li>Moscou</li></settlement></list><tree><country name="Russie"><region name="District fédéral central"><name sortKey="Ginzburg, V P" sort="Ginzburg, V P" uniqKey="Ginzburg V" first="V. P." last="Ginzburg">V. P. Ginzburg</name></region><name sortKey="Ghendon, Y Z" sort="Ghendon, Y Z" uniqKey="Ghendon Y" first="Y. Z." last="Ghendon">Y. Z. Ghendon</name><name sortKey="Rosina, E E" sort="Rosina, E E" uniqKey="Rosina E" first="E. 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